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- Title
Requirement for IL-13 independently of IL-4 in experimental asthma.
- Authors
Grünig, G; Warnock, M; Wakil, A E; Venkayya, R; Brombacher, F; Rennick, D M; Sheppard, D; Mohrs, M; Donaldson, D D; Locksley, R M; Corry, D B
- Abstract
The pathogenesis of asthma reflects, in part, the activity of T cell cytokines. Murine models support participation of interleukin-4 (IL-4) and the IL-4 receptor in asthma. Selective neutralization of IL-13, a cytokine related to IL-4 that also binds to the alpha chain of the IL-4 receptor, ameliorated the asthma phenotype, including airway hyperresponsiveness, eosinophil recruitment, and mucus overproduction. Administration of either IL-13 or IL-4 conferred an asthma-like phenotype to nonimmunized T cell-deficient mice by an IL-4 receptor alpha chain-dependent pathway. This pathway may underlie the genetic associations of asthma with both the human 5q31 locus and the IL-4 receptor.
- Publication
Science (New York, N.Y.), 1998, Vol 282, Issue 5397, p2261
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.282.5397.2261