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- Title
Interleukin-13: central mediator of allergic asthma.
- Authors
Wills-Karp, M; Luyimbazi, J; Xu, X; Schofield, B; Neben, T Y; Karp, C L; Donaldson, D D
- Abstract
The worldwide incidence, morbidity, and mortality of allergic asthma are increasing. The pathophysiological features of allergic asthma are thought to result from the aberrant expansion of CD4(+) T cells producing the type 2 cytokines interleukin-4 (IL-4) and IL-5, although a necessary role for these cytokines in allergic asthma has not been demonstrable. The type 2 cytokine IL-13, which shares a receptor component and signaling pathways with IL-4, was found to be necessary and sufficient for the expression of allergic asthma. IL-13 induces the pathophysiological features of asthma in a manner that is independent of immunoglobulin E and eosinophils. Thus, IL-13 is critical to allergen-induced asthma but operates through mechanisms other than those that are classically implicated in allergic responses.
- Publication
Science (New York, N.Y.), 1998, Vol 282, Issue 5397, p2258
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.282.5397.2258