We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Patterning of cortical efferent projections by semaphorin-neuropilin interactions.
- Authors
Polleux, F; Giger, R J; Ginty, D D; Kolodkin, A L; Ghosh, A
- Abstract
Cortical neurons communicate with various cortical and subcortical targets by way of stereotyped axon projections through the white matter. Slice overlay experiments indicate that the initial growth of cortical axons toward the white matter is regulated by a diffusible chemorepulsive signal localized near the marginal zone. Semaphorin III is a major component of this diffusible signal, and cortical neurons transduce this signal by way of the neuropilin-1 receptor. These observations indicate that semaphorin-neuropilin interactions play a critical role in the initial patterning of projections in the developing cortex.
- Publication
Science (New York, N.Y.), 1998, Vol 282, Issue 5395, p1904
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.282.5395.1904