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- Title
Regulation of the proinflammatory effects of Fas ligand (CD95L).
- Authors
Chen, J J; Sun, Y; Nabel, G J
- Abstract
Fas ligand (CD95L) inhibits T cell function in immune-privileged organs such as the eye and testis, yet in most tissues CD95L expression induces potent inflammatory responses. With a stably transfected colon carcinoma cell line, CT26-CD95L, the molecular basis for these divergent responses was defined. When injected subcutaneously, rejection of CT26-CD95L was caused by neutrophils activated by CD95L. CT26-CD95L survived in the intraocular space because of the presence of transforming growth factor-beta (TGF-beta), which inhibited neutrophil activation. Providing TGF-beta to subcutaneous sites protected against tumor rejection. Thus, these cytokines together generate a microenvironment that promotes immunologic tolerance, which may aid in the amelioration of allograft rejection.
- Publication
Science (New York, N.Y.), 1998, Vol 282, Issue 5394, p1714
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.282.5394.1714