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- Title
Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum.
- Authors
Gardner, M J; Tettelin, H; Carucci, D J; Cummings, L M; Aravind, L; Koonin, E V; Shallom, S; Mason, T; Yu, K; Fujii, C; Pederson, J; Shen, K; Jing, J; Aston, C; Lai, Z; Schwartz, D C; Pertea, M; Salzberg, S; Zhou, L; Sutton, G G; Clayton, R; White, O; Smith, H O; Fraser, C M; Adams, M D; Venter, J C; Hoffman, S L
- Abstract
Chromosome 2 of Plasmodium falciparum was sequenced; this sequence contains 947,103 base pairs and encodes 210 predicted genes. In comparison with the Saccharomyces cerevisiae genome, chromosome 2 has a lower gene density, introns are more frequent, and proteins are markedly enriched in nonglobular domains. A family of surface proteins, rifins, that may play a role in antigenic variation was identified. The complete sequencing of chromosome 2 has shown that sequencing of the A+T-rich P. falciparum genome is technically feasible.
- Publication
Science (New York, N.Y.), 1998, Vol 282, Issue 5391, p1126
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.282.5391.1126