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- Title
Extended life-span and stress resistance in the Drosophila mutant methuselah.
- Authors
Lin, Y J; Seroude, L; Benzer, S
- Abstract
Toward a genetic dissection of the processes involved in aging, a screen for gene mutations that extend life-span in Drosophila melanogaster was performed. The mutant line methuselah (mth) displayed approximately 35 percent increase in average life-span and enhanced resistance to various forms of stress, including starvation, high temperature, and dietary paraquat, a free-radical generator. The mth gene predicted a protein with homology to several guanosine triphosphate-binding protein-coupled seven-transmembrane domain receptors. Thus, the organism may use signal transduction pathways to modulate stress response and life-span.
- Publication
Science (New York, N.Y.), 1998, Vol 282, Issue 5390, p943
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.282.5390.943