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- Title
Genome sequence of an obligate intracellular pathogen of humans: Chlamydia trachomatis.
- Authors
Stephens, R S; Kalman, S; Lammel, C; Fan, J; Marathe, R; Aravind, L; Mitchell, W; Olinger, L; Tatusov, R L; Zhao, Q; Koonin, E V; Davis, R W
- Abstract
Analysis of the 1,042,519-base pair Chlamydia trachomatis genome revealed unexpected features related to the complex biology of chlamydiae. Although chlamydiae lack many biosynthetic capabilities, they retain functions for performing key steps and interconversions of metabolites obtained from their mammalian host cells. Numerous potential virulence-associated proteins also were characterized. Several eukaryotic chromatin-associated domain proteins were identified, suggesting a eukaryotic-like mechanism for chlamydial nucleoid condensation and decondensation. The phylogenetic mosaic of chlamydial genes, including a large number of genes with phylogenetic origins from eukaryotes, implies a complex evolution for adaptation to obligate intracellular parasitism.
- Publication
Science (New York, N.Y.), 1998, Vol 282, Issue 5389, p754
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.282.5389.754