We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
The transcriptional program of sporulation in budding yeast.
- Authors
Chu, S; DeRisi, J; Eisen, M; Mulholland, J; Botstein, D; Brown, P O; Herskowitz, I
- Abstract
Diploid cells of budding yeast produce haploid cells through the developmental program of sporulation, which consists of meiosis and spore morphogenesis. DNA microarrays containing nearly every yeast gene were used to assay changes in gene expression during sporulation. At least seven distinct temporal patterns of induction were observed. The transcription factor Ndt80 appeared to be important for induction of a large group of genes at the end of meiotic prophase. Consensus sequences known or proposed to be responsible for temporal regulation could be identified solely from analysis of sequences of coordinately expressed genes. The temporal expression pattern provided clues to potential functions of hundreds of previously uncharacterized genes, some of which have vertebrate homologs that may function during gametogenesis.
- Publication
Science (New York, N.Y.), 1998, Vol 282, Issue 5389, p699
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.282.5389.699