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- Title
Inhibition of toxic epidermal necrolysis by blockade of CD95 with human intravenous immunoglobulin.
- Authors
Viard, I; Wehrli, P; Bullani, R; Schneider, P; Holler, N; Salomon, D; Hunziker, T; Saurat, J H; Tschopp, J; French, L E
- Abstract
Toxic epidermal necrolysis (TEN, Lyell's syndrome) is a severe adverse drug reaction in which keratinocytes die and large sections of epidermis separate from the dermis. Keratinocytes normally express the death receptor Fas (CD95); those from TEN patients were found to express lytically active Fas ligand (FasL). Antibodies present in pooled human intravenous immunoglobulins (IVIG) blocked Fas-mediated keratinocyte death in vitro. In a pilot study, 10 consecutive individuals with clinically and histologically confirmed TEN were treated with IVIG; disease progression was rapidly reversed and the outcome was favorable in all cases. Thus, Fas-FasL interactions are directly involved in the epidermal necrolysis of TEN, and IVIG may be an effective treatment.
- Publication
Science (New York, N.Y.), 1998, Vol 282, Issue 5388, p490
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.282.5388.490