We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Activation of apoptosis signal-regulating kinase 1 (ASK1) by the adapter protein Daxx.
- Authors
Chang, H Y; Nishitoh, H; Yang, X; Ichijo, H; Baltimore, D
- Abstract
The Fas death receptor can activate the Jun NH2-terminal kinase (JNK) pathway through the receptor-associated protein Daxx. Daxx was found to activate the JNK kinase kinase ASK1, and overexpression of a kinase-deficient ASK1 mutant inhibited Fas- and Daxx-induced apoptosis and JNK activation. Fas activation induced Daxx to interact with ASK1, which consequently relieved an inhibitory intramolecular interaction between the amino- and carboxyl-termini of ASK1, activating its kinase activity. The Daxx-ASK1 connection completes a signaling pathway from a cell surface death receptor to kinase cascades that modulate nuclear transcription factors.
- Publication
Science (New York, N.Y.), 1998, Vol 281, Issue 5384, p1860
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.281.5384.1860