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- Title
A mammalian scaffold complex that selectively mediates MAP kinase activation.
- Authors
Whitmarsh, A J; Cavanagh, J; Tournier, C; Yasuda, J; Davis, R J
- Abstract
The c-Jun NH2-terminal kinase (JNK) group of mitogen-activated protein (MAP) kinases is activated by the exposure of cells to multiple forms of stress. A putative scaffold protein was identified that interacts with multiple components of the JNK signaling pathway, including the mixed-lineage group of MAP kinase kinase kinases (MLK), the MAP kinase kinase MKK7, and the MAP kinase JNK. This scaffold protein selectively enhanced JNK activation by the MLK signaling pathway. These data establish that a mammalian scaffold protein can mediate activation of a MAP kinase signaling pathway.
- Publication
Science (New York, N.Y.), 1998, Vol 281, Issue 5383, p1671
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.281.5383.1671