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- Title
Caspases: enemies within.
- Authors
Thornberry, N A; Lazebnik, Y
- Abstract
Apoptosis, an evolutionarily conserved form of cell suicide, requires specialized machinery. The central component of this machinery is a proteolytic system involving a family of proteases called caspases. These enzymes participate in a cascade that is triggered in response to proapoptotic signals and culminates in cleavage of a set of proteins, resulting in disassembly of the cell. Understanding caspase regulation is intimately linked to the ability to rationally manipulate apoptosis for therapeutic gain.
- Publication
Science (New York, N.Y.), 1998, Vol 281, Issue 5381, p1312
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.281.5381.1312