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- Title
IEX-1L, an apoptosis inhibitor involved in NF-kappaB-mediated cell survival.
- Authors
Wu, M X; Ao, Z; Prasad, K V; Wu, R; Schlossman, S F
- Abstract
Transcription factors of the nuclear factor-kappaB/rel (NF-kappaB) family may be important in cell survival by regulating unidentified, anti-apoptotic genes. One such gene that protects cells from apoptosis induced by Fas or tumor necrosis factor type alpha (TNF), IEX-1L, is described here. Its transcription induced by TNF was decreased in cells with defective NF-kappaB activation, rendering them sensitive to TNF-induced apoptosis, which was abolished by transfection with IEX-1L. In support, overexpression of antisense IEX-1L partially blocked TNF-induced expression of IEX-1L and sensitized normal cells to killing. This study demonstrates a key role of IEX-1L in cellular resistance to TNF-induced apoptosis.
- Publication
Science (New York, N.Y.), 1998, Vol 281, Issue 5379, p998
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.281.5379.998