We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
DARPP-32: regulator of the efficacy of dopaminergic neurotransmission.
- Authors
Fienberg, A A; Hiroi, N; Mermelstein, P G; Song, W; Snyder, G L; Nishi, A; Cheramy, A; O'Callaghan, J P; Miller, D B; Cole, D G; Corbett, R; Haile, C N; Cooper, D C; Onn, S P; Grace, A A; Ouimet, C C; White, F J; Hyman, S E; Surmeier, D J; Girault, J; Nestler, E J; Greengard, P
- Abstract
Dopaminergic neurons exert a major modulatory effect on the forebrain. Dopamine and adenosine 3',5'-monophosphate-regulated phosphoprotein (32 kilodaltons) (DARPP-32), which is enriched in all neurons that receive a dopaminergic input, is converted in response to dopamine into a potent protein phosphatase inhibitor. Mice generated to contain a targeted disruption of the DARPP-32 gene showed profound deficits in their molecular, electrophysiological, and behavioral responses to dopamine, drugs of abuse, and antipsychotic medication. The results show that DARPP-32 plays a central role in regulating the efficacy of dopaminergic neurotransmission.
- Publication
Science (New York, N.Y.), 1998, Vol 281, Issue 5378, p838
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.281.5378.838