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- Title
Coupled gating between individual skeletal muscle Ca2+ release channels (ryanodine receptors)
- Authors
Marx, S O; Ondrias, K; Marks, A R
- Abstract
Excitation-contraction coupling in skeletal muscle requires the release of intracellular calcium ions (Ca2+) through ryanodine receptor (RyR1) channels in the sarcoplasmic reticulum. Half of the RyR1 channels are activated by voltage-dependent Ca2+ channels in the plasma membrane. In planar lipid bilayers, RyR1 channels exhibited simultaneous openings and closings, termed "coupled gating." Addition of the channel accessory protein FKBP12 induced coupled gating, and removal of FKBP12 uncoupled channels. Coupled gating provides a mechanism by which RyR1 channels that are not associated with voltage-dependent Ca2+ channels can be regulated.
- Publication
Science (New York, N.Y.), 1998, Vol 281, Issue 5378, p818
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.281.5378.818