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- Title
Stabilization of interleukin-2 mRNA by the c-Jun NH2-terminal kinase pathway.
- Authors
Chen, C Y; Del Gatto-Konczak, F; Wu, Z; Karin, M
- Abstract
Signaling pathways that stabilize interleukin-2 (IL-2) messenger RNA (mRNA) in activated T cells were examined. IL-2 mRNA contains at least two cis elements that mediated its stabilization in response to different signals, including activation of c-Jun amino-terminal kinase (JNK). This response was mediated through a cis element encompassing the 5' untranslated region (UTR) and the beginning of the coding region. IL-2 transcripts lacking this 5' element no longer responded to JNK activation but were still responsive to other signals generated during T cell activation, which were probably sensed through the 3' UTR. Thus, multiple elements within IL-2 mRNA modulate its stability in a combinatorial manner, and the JNK pathway controls turnover as well as synthesis of IL-2 mRNA.
- Publication
Science (New York, N.Y.), 1998, Vol 280, Issue 5371, p1945
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.280.5371.1945