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- Title
Requirement for gammadelta T cells in allergic airway inflammation.
- Authors
Zuany-Amorim, C; Ruffié, C; Hailé, S; Vargaftig, B B; Pereira, P; Pretolani, M
- Abstract
The factors that contribute to allergic asthma are unclear but the resulting condition is considered a consequence of a type-2 T helper (TH2) cell response. In a model of pulmonary allergic inflammation, mice that lacked gammadelta T cells had decreases in specific immunoglobulin E (IgE) and IgG1 and pulmonary interleukin-5 (IL-5) release as well as in eosinophil and T cell infiltration compared with wild-type mice. These responses were restored by administration of IL-4 to gammadelta T cell-deficient mice during the primary immunization. Thus, gammadelta T cells are essential for inducing IL-4-dependent IgE and IgG1 responses and for TH2-mediated airway inflammation to peptidic antigens.
- Publication
Science (New York, N.Y.), 1998, Vol 280, Issue 5367, p1265
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.280.5367.1265