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- Title
Gastrointestinal tract as a major site of CD4+ T cell depletion and viral replication in SIV infection.
- Authors
Veazey, R S; DeMaria, M; Chalifoux, L V; Shvetz, D E; Pauley, D R; Knight, H L; Rosenzweig, M; Johnson, R P; Desrosiers, R C; Lackner, A A
- Abstract
Human and simian immunodeficiency virus (HIV and SIV) replicate optimally in activated memory CD4(+) T cells, a cell type that is abundant in the intestine. SIV infection of rhesus monkeys resulted in profound and selective depletion of CD4+ T cells in the intestine within days of infection, before any such changes in peripheral lymphoid tissues. The loss of CD4+ T cells in the intestine occurred coincident with productive infection of large numbers of mononuclear cells at this site. The intestine appears to be a major target for SIV replication and the major site of CD4+ T cell loss in early SIV infection.
- Publication
Science (New York, N.Y.), 1998, Vol 280, Issue 5362, p427
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.280.5362.427