We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Crystal structure and evolution of a transfer RNA splicing enzyme.
- Authors
Li, H; Trotta, C R; Abelson, J
- Abstract
The splicing of transfer RNA precursors is similar in Eucarya and Archaea. In both kingdoms an endonuclease recognizes the splice sites and releases the intron, but the mechanism of splice site recognition is different in each kingdom. The crystal structure of the endonuclease from the archaeon Methanococcus jannaschii was determined to a resolution of 2.3 angstroms. The structure indicates that the cleavage reaction is similar to that of ribonuclease A and the arrangement of the active sites is conserved between the archaeal and eucaryal enzymes. These results suggest an evolutionary pathway for splice site recognition.
- Publication
Science (New York, N.Y.), 1998, Vol 280, Issue 5361, p279
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.280.5361.279