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- Title
Monoallelic expression of the interleukin-2 locus.
- Authors
Holländer, G A; Zuklys, S; Morel, C; Mizoguchi, E; Mobisson, K; Simpson, S; Terhorst, C; Wishart, W; Golan, D E; Bhan, A K; Burakoff, S J
- Abstract
The lymphokine interleukin-2 (IL-2) is responsible for autocrine cell cycle progression and regulation of immune responses. Uncontrolled secretion of IL-2 results in adverse reactions ranging from anergy, to aberrant T cell activation, to autoimmunity. With the use of fluorescent in situ hybridization and single-cell polymerase chain reaction in cells with different IL-2 alleles, IL-2 expression in mature thymocytes and T cells was found to be tightly controlled by monoallelic expression. Because IL-2 is encoded at a nonimprinted autosomal locus, this result represents an unusual regulatory mode for controlling the precise expression of a single gene.
- Publication
Science (New York, N.Y.), 1998, Vol 279, Issue 5359, p2118
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.279.5359.2118