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- Title
Molecular mimicry by herpes simplex virus-type 1: autoimmune disease after viral infection.
- Authors
Zhao, Z S; Granucci, F; Yeh, L; Schaffer, P A; Cantor, H
- Abstract
Viral infection is sometimes associated with the initiation or exacerbation of autoimmune disease, although the underlying mechanisms remain unclear. One proposed mechanism is that viral determinants that mimic host antigens trigger self-reactive T cell clones to destroy host tissue. An epitope expressed by a coat protein of herpes simplex virus-type 1 (HSV-1) KOS strain has now been shown to be recognized by autoreactive T cells that target corneal antigens in a murine model of autoimmune herpes stromal keratitis. Mutant HSV-1 viruses that lacked this epitope did not induce autoimmune disease. Thus, expression of molecular mimics can influence the development of autoimmune disease after viral infection.
- Publication
Science (New York, N.Y.), 1998, Vol 279, Issue 5355, p1344
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.279.5355.1344