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- Title
Mismatch repair co-opted by hypermutation.
- Authors
Cascalho, M; Wong, J; Steinberg, C; Wabl, M
- Abstract
Mice homozygous for a disrupted allele of the mismatch repair gene Pms2 have a mutator phenotype. When this allele is crossed into quasi-monoclonal (QM) mice, which have a very limited B cell repertoire, homozygotes have fewer somatic mutations at the immunoglobulin heavy chain and lambda chain loci than do heterozygotes or wild-type QM mice. That is, mismatch repair seems to contribute to somatic hypermutation rather than stifling it. It is suggested that at immunoglobulin loci in hypermutable B cells, mismatched base pairs are "corrected" according to the newly synthesized DNA strand, thereby fixing incipient mutations instead of eliminating them.
- Publication
Science (New York, N.Y.), 1998, Vol 279, Issue 5354, p1207
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.279.5354.1207