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- Title
Alopecia universalis associated with a mutation in the human hairless gene.
- Authors
Ahmad, W; Faiyaz ul Haque, M; Brancolini, V; Tsou, H C; ul Haque, S; Lam, H; Aita, V M; Owen, J; deBlaquiere, M; Frank, J; Cserhalmi-Friedman, P B; Leask, A; McGrath, J A; Peacocke, M; Ahmad, M; Ott, J; Christiano, A M
- Abstract
There are several forms of hereditary human hair loss, known collectively as alopecias, the molecular bases of which are entirely unknown. A kindred with a rare, recessively inherited type of alopecia universalis was used to search for a locus by homozygosity mapping, and linkage was established in a 6-centimorgan interval on chromosome 8p12 (the logarithm of the odds favoring linkage score was 6.19). The human homolog of a murine gene, hairless, was localized in this interval by radiation hybrid mapping, and a missense mutation was found in affected individuals. Human hairless encodes a putative single zinc finger transcription factor protein with restricted expression in the brain and skin.
- Publication
Science (New York, N.Y.), 1998, Vol 279, Issue 5351, p720
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.279.5351.720