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- Title
Interaction of a Golgi-associated kinesin-like protein with Rab6.
- Authors
Echard, A; Jollivet, F; Martinez, O; Lacapère, J J; Rousselet, A; Janoueix-Lerosey, I; Goud, B
- Abstract
Rab guanosine triphosphatases regulate vesicular transport and membrane traffic within eukaryotic cells. Here, a kinesin-like protein that interacts with guanosine triphosphate (GTP)-bound forms of Rab6 was identified. This protein, termed Rabkinesin-6, was localized to the Golgi apparatus and shown to play a role in the dynamics of this organelle. The carboxyl-terminal domain of Rabkinesin-6, which contains the Rab6-interacting domain, inhibited the effects of Rab6-GTP on intracellular transport. Thus, a molecular motor is a potential effector of a Rab protein, and coordinated action between members of these two families of proteins could control membrane dynamics and directional vesicular traffic.
- Publication
Science (New York, N.Y.), 1998, Vol 279, Issue 5350, p580
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.279.5350.580