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- Title
Rho GTPases and the actin cytoskeleton.
- Authors
Hall, A
- Abstract
The actin cytoskeleton mediates a variety of essential biological functions in all eukaryotic cells. In addition to providing a structural framework around which cell shape and polarity are defined, its dynamic properties provide the driving force for cells to move and to divide. Understanding the biochemical mechanisms that control the organization of actin is thus a major goal of contemporary cell biology, with implications for health and disease. Members of the Rho family of small guanosine triphosphatases have emerged as key regulators of the actin cytoskeleton, and furthermore, through their interaction with multiple target proteins, they ensure coordinated control of other cellular activities such as gene transcription and adhesion.
- Publication
Science (New York, N.Y.), 1998, Vol 279, Issue 5350, p509
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.279.5350.509