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- Title
IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling.
- Authors
Muzio, M; Ni, J; Feng, P; Dixit, V M
- Abstract
The interleukin-1 receptor (IL-1R) signaling pathway leads to nuclear factor kappa B (NF-kappaB) activation in mammals and is similar to the Toll pathway in Drosophila: the IL-1R-associated kinase (IRAK) is homologous to Pelle. Two additional proximal mediators were identified that are required for IL-1R-induced NF-kappaB activation: IRAK-2, a Pelle family member, and MyD88, a death domain-containing adapter molecule. Both associate with the IL-1R signaling complex. Dominant negative forms of either attenuate IL-1R-mediated NF-kappaB activation. Therefore, IRAK-2 and MyD88 may provide additional therapeutic targets for inhibiting IL-1-induced inflammation.
- Publication
Science (New York, N.Y.), 1997, Vol 278, Issue 5343, p1612
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.278.5343.1612