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- Title
Inhibition of HIV-1 infection by the beta-chemokine MDC.
- Authors
Pal, R; Garzino-Demo, A; Markham, P D; Burns, J; Brown, M; Gallo, R C; DeVico, A L
- Abstract
CD8(+) T lymphocytes from individuals infected with human immunodeficiency virus-type 1 (HIV-1) secrete a soluble activity that suppresses infection by HIV-1. A protein associated with this activity was purified from the culture supernatant of an immortalized CD8(+) T cell clone and identified as the beta-chemokine macrophage-derived chemokine (MDC). MDC suppressed infection of CD8(+) cell-depleted peripheral blood mononuclear cells by primary non-syncytium-inducing and syncytium-inducing isolates of HIV-1 and the T cell line-adapted isolate HIV-1IIIB. MDC was expressed in activated, but not resting, peripheral blood mononuclear cells and binds a receptor on activated primary T cells. These observations indicate that beta-chemokines are responsible for a major proportion of HIV-1-specific suppressor activity produced by primary T cells.
- Publication
Science (New York, N.Y.), 1997, Vol 278, Issue 5338, p695
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.278.5338.695