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- Title
The endocrinology of aging.
- Authors
Lamberts, S W; van den Beld, A W; van der Lely, A J
- Abstract
Most aging individuals die from atherosclerosis, cancer, or dementia; but in the oldest old, loss of muscle strength resulting in frailty is the limiting factor for an individual's chances of living an independent life until death. Three hormonal systems show decreasing circulating hormone concentrations during normal aging: (i) estrogen (in menopause) and testosterone (in andropause), (ii) dehydroepiandrosterone and its sulphate (in adrenopause), and (iii) the growth hormone/insulin-like growth factor I axis (in somatopause). Physical changes during aging have been considered physiologic, but there is evidence that some of these changes are related to this decline in hormonal activity. Hormone replacement strategies have been developed, but many of their aspects remain controversial, and increasing blood hormone levels in aging individuals to those found during mid-adult life has not been uniformly proven to be safe and of benefit.
- Publication
Science (New York, N.Y.), 1997, Vol 278, Issue 5337, p419
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.278.5337.419