We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
NF-AT activation induced by a CAML-interacting member of the tumor necrosis factor receptor superfamily.
- Authors
von Bülow, G U; Bram, R J
- Abstract
Activation of the nuclear factor of activated T cells transcription factor (NF-AT) is a key event underlying lymphocyte action. The CAML (calcium-modulator and cyclophilin ligand) protein is a coinducer of NF-AT activation when overexpressed in Jurkat T cells. A member of the tumor necrosis factor receptor superfamily was isolated by virtue of its affinity for CAML. Cross-linking of this lymphocyte-specific protein, designated TACI (transmembrane activator and CAML-interactor), on the surface of transfected Jurkat cells with TACI-specific antibodies led to activation of the transcription factors NF-AT, AP-1, and NFkappaB. TACI-induced activation of NF-AT was specifically blocked by a dominant-negative CAML mutant, thus implicating CAML as a signaling intermediate.
- Publication
Science (New York, N.Y.), 1997, Vol 278, Issue 5335, p138
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.278.5335.138