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- Title
Selective expression of the eotaxin receptor CCR3 by human T helper 2 cells.
- Authors
Sallusto, F; Mackay, C R; Lanzavecchia, A
- Abstract
There is growing evidence that T helper cell subsets (TH1 and TH2) can be differentially recruited to promote different types of inflammatory reactions. Murine TH1 but not TH2 cells are recruited through P- and E-selectin into inflamed tissues, where they induce delayed-type hypersensitivity reactions. The human eotaxin-receptor CCR3, originally described on eosinophils and basophils, was also found to be expressed by TH2 cells. An antibody to CCR3 was used to isolate T cells from peripheral blood that give rise to TH2-polarized cell lines and to identify TH2 cells derived from naïve T cells in vitro. Eotaxin stimulated increases in intracellular calcium and chemotaxis of CCR3(+) T cells. The attraction of TH2 cells by eotaxin could represent a key mechanism in allergic reactions, because it promotes the allergen-driven production of interleukin-4 and interleukin-5 necessary to activate basophils and eosinophils.
- Publication
Science (New York, N.Y.), 1997, Vol 277, Issue 5334, p2005
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.277.5334.2005