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- Title
Binding of neuroligins to PSD-95.
- Authors
Irie, M; Hata, Y; Takeuchi, M; Ichtchenko, K; Toyoda, A; Hirao, K; Takai, Y; Rosahl, T W; Südhof, T C
- Abstract
PSD-95 is a component of postsynaptic densities in central synapses. It contains three PDZ domains that localize N-methyl-D-aspartate receptor subunit 2 (NMDA2 receptor) and K+ channels to synapses. In mouse forebrain, PSD-95 bound to the cytoplasmic COOH-termini of neuroligins, which are neuronal cell adhesion molecules that interact with beta-neurexins and form intercellular junctions. Neuroligins bind to the third PDZ domain of PSD-95, whereas NMDA2 receptors and K+ channels interact with the first and second PDZ domains. Thus different PDZ domains of PSD-95 are specialized for distinct functions. PSD-95 may recruit ion channels and neurotransmitter receptors to intercellular junctions formed between neurons by neuroligins and beta-neurexins.
- Publication
Science (New York, N.Y.), 1997, Vol 277, Issue 5331, p1511
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.277.5331.1511