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- Title
daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans.
- Authors
Kimura, K D; Tissenbaum, H A; Liu, Y; Ruvkun, G
- Abstract
A C. elegans neurosecretory signaling system regulates whether animals enter the reproductive life cycle or arrest development at the long-lived dauer diapause stage. daf-2, a key gene in the genetic pathway that mediates this endocrine signaling, encodes an insulin receptor family member. Decreases in DAF-2 signaling induce metabolic and developmental changes, as in mammalian metabolic control by the insulin receptor. Decreased DAF-2 signaling also causes an increase in life-span. Life-span regulation by insulin-like metabolic control is analogous to mammalian longevity enhancement induced by caloric restriction, suggesting a general link between metabolism, diapause, and longevity.
- Publication
Science (New York, N.Y.), 1997, Vol 277, Issue 5328, p942
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.277.5328.942