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- Title
Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors.
- Authors
Sheridan, J P; Marsters, S A; Pitti, R M; Gurney, A; Skubatch, M; Baldwin, D; Ramakrishnan, L; Gray, C L; Baker, K; Wood, W I; Goddard, A D; Godowski, P; Ashkenazi, A
- Abstract
TRAIL (also called Apo2L) belongs to the tumor necrosis factor family, activates rapid apoptosis in tumor cells, and binds to the death-signaling receptor DR4. Two additional TRAIL receptors were identified. The receptor designated death receptor 5 (DR5) contained a cytoplasmic death domain and induced apoptosis much like DR4. The receptor designated decoy receptor 1 (DcR1) displayed properties of a glycophospholipid-anchored cell surface protein. DcR1 acted as a decoy receptor that inhibited TRAIL signaling. Thus, a cell surface mechanism exists for the regulation of cellular responsiveness to pro-apoptotic stimuli.
- Publication
Science (New York, N.Y.), 1997, Vol 277, Issue 5327, p818
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.277.5327.818