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- Title
Bcl-2: prolonging life in a transgenic mouse model of familial amyotrophic lateral sclerosis.
- Authors
Kostic, V; Jackson-Lewis, V; de Bilbao, F; Dubois-Dauphin, M; Przedborski, S
- Abstract
Mutations in the gene encoding copper/zinc superoxide dismutase enzyme produce an animal model of familial amyotrophic lateral sclerosis (FALS), a fatal disorder characterized by paralysis. Overexpression of the proto-oncogene bcl-2 delayed onset of motor neuron disease and prolonged survival in transgenic mice expressing the FALS-linked mutation in which glycine is substituted by alanine at position 93. It did not, however, alter the duration of the disease. Overexpression of bcl-2 also attenuated the magnitude of spinal cord motor neuron degeneration in the FALS-transgenic mice.
- Publication
Science (New York, N.Y.), 1997, Vol 277, Issue 5325, p559
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.277.5325.559