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- Title
Differential effects of cytolytic T cell subsets on intracellular infection.
- Authors
Stenger, S; Mazzaccaro, R J; Uyemura, K; Cho, S; Barnes, P F; Rosat, J P; Sette, A; Brenner, M B; Porcelli, S A; Bloom, B R; Modlin, R L
- Abstract
In analyzing mechanisms of protection against intracellular infections, a series of human CD1-restricted T cell lines of two distinct phenotypes were derived. Both CD4(-)CD8(-) (double-negative) T cells and CD8(+) T cells efficiently lysed macrophages infected with Mycobacterium tuberculosis. The cytotoxicity of CD4(-)CD8(-) T cells was mediated by Fas-FasL interaction and had no effect on the viability of the mycobacteria. The CD8(+) T cells lysed infected macrophages by a Fas-independent, granule-dependent mechanism that resulted in killing of bacteria. These data indicate that two phenotypically distinct subsets of human cytolytic T lymphocytes use different mechanisms to kill infected cells and contribute in different ways to host defense against intracellular infection.
- Publication
Science (New York, N.Y.), 1997, Vol 276, Issue 5319, p1684
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.276.5319.1684