We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Control of inflammation, cytokine expression, and germinal center formation by BCL-6.
- Authors
Dent, A L; Shaffer, A L; Yu, X; Allman, D; Staudt, L M
- Abstract
The gene encoding the BCL-6 transcriptional repressor is frequently translocated and mutated in diffuse large cell lymphoma. Mice with a disrupted BCL-6 gene developed myocarditis and pulmonary vasculitis, had no germinal centers, and had increased expression of T helper cell type 2 cytokines. The BCL-6 DNA recognition motif resembled sites bound by the STAT (signal transducers and activators of transcription) transcription factors, which mediate cytokine signaling. BCL-6 could repress interleukin-4 (IL-4)-induced transcription when bound to a site recognized by the IL-4-responsive transcription factor Stat6. Thus, dysregulation of STAT-responsive genes may underlie the inflammatory disease in BCL-6-deficient mice and participate in lymphoid malignancies.
- Publication
Science (New York, N.Y.), 1997, Vol 276, Issue 5312, p589
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.276.5312.589