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- Title
Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC.
- Authors
Morin, P J; Sparks, A B; Korinek, V; Barker, N; Clevers, H; Vogelstein, B; Kinzler, K W
- Abstract
Inactivation of the adenomatous polyposis coli (APC) tumor suppressor gene initiates colorectal neoplasia. One of the biochemical activities associated with the APC protein is down-regulation of transcriptional activation mediated by beta-catenin and T cell transcription factor 4 (Tcf-4). The protein products of mutant APC genes present in colorectal tumors were found to be defective in this activity. Furthermore, colorectal tumors with intact APC genes were found to contain activating mutations of beta-catenin that altered functionally significant phosphorylation sites. These results indicate that regulation of beta-catenin is critical to APC's tumor suppressive effect and that this regulation can be circumvented by mutations in either APC or beta-catenin.
- Publication
Science (New York, N.Y.), 1997, Vol 275, Issue 5307, p1787
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.275.5307.1787