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- Title
Isolation of a common receptor for Coxsackie B viruses and adenoviruses 2 and 5.
- Authors
Bergelson, J M; Cunningham, J A; Droguett, G; Kurt-Jones, E A; Krithivas, A; Hong, J S; Horwitz, M S; Crowell, R L; Finberg, R W
- Abstract
A complementary DNA clone has been isolated that encodes a coxsackievirus and adenovirus receptor (CAR). When transfected with CAR complementary DNA, nonpermissive hamster cells became susceptible to coxsackie B virus attachment and infection. Furthermore, consistent with previous studies demonstrating that adenovirus infection depends on attachment of a viral fiber to the target cell, CAR-transfected hamster cells bound adenovirus in a fiber-dependent fashion and showed a 100-fold increase in susceptibility to virus-mediated gene transfer. Identification of CAR as a receptor for these two unrelated and structurally distinct viral pathogens is important for understanding viral pathogenesis and has implications for therapeutic gene delivery with adenovirus vectors.
- Publication
Science (New York, N.Y.), 1997, Vol 275, Issue 5304, p1320
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.275.5304.1320