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- Title
Formation of actin stress fibers and focal adhesions enhanced by Rho-kinase.
- Authors
Amano, M; Chihara, K; Kimura, K; Fukata, Y; Nakamura, N; Matsuura, Y; Kaibuchi, K
- Abstract
The small guanosine triphosphatase (GTPase) Rho is implicated in the formation of stress fibers and focal adhesions in fibroblasts stimulated by extracellular signals such as lysophosphatidic acid (LPA). Rho-kinase is activated by Rho and may mediate some biological effects of Rho. Microinjection of the catalytic domain of Rho-kinase into serum-starved Swiss 3T3 cells induced the formation of stress fibers and focal adhesions, whereas microinjection of the inactive catalytic domain, the Rho-binding domain, or the pleckstrin-homology domain inhibited the LPA-induced formation of stress fibers and focal adhesions. Thus, Rho-kinase appears to mediate signals from Rho and to induce the formation of stress fibers and focal adhesions.
- Publication
Science (New York, N.Y.), 1997, Vol 275, Issue 5304, p1308
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.275.5304.1308