We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Structural and functional conservation of the Caenorhabditis elegans timing gene clk-1.
- Authors
Ewbank, J J; Barnes, T M; Lakowski, B; Lussier, M; Bussey, H; Hekimi, S
- Abstract
Mutations in the Caenorhabditis elegans gene clk-1 affect biological timing and extend longevity. The gene clk-1 was identified, and the cloned gene complemented the clk-1 phenotypes and restored normal longevity. The CLK-1 protein was found to be conserved among eukaryotes, including humans, and structurally similar to the yeast metabolic regulator Cat5p (also called Coq7p). These proteins contain a tandem duplication of a core 82-residue domain. clk-1 complemented the phenotype of cat5/coq7 null mutants, demonstrating that clk-1 and CAT5/COQ7 share biochemical function and that clk-1 acts at the level of cellular physiology.
- Publication
Science (New York, N.Y.), 1997, Vol 275, Issue 5302, p980
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.275.5302.980