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- Title
DCP-1, a Drosophila cell death protease essential for development.
- Authors
Song, Z; McCall, K; Steller, H
- Abstract
Apoptosis, a form of cellular suicide, involves the activation of CED-3-related cysteine proteases (caspases). The regulation of caspases by apoptotic signals and the precise mechanism by which they kill the cell remain unknown. In Drosophila, different death-inducing stimuli induce the expression of the apoptotic activator reaper. Cell killing by reaper and two genetically linked apoptotic activators, hid and grim, requires caspase activity. A Drosophila caspase, named Drosophila caspase-1 (DCP-1), was identified and found to be structurally and biochemically similar to Caenorhabditis elegans CED-3. Loss of zygotic DCP-1 function in Drosophila caused larval lethality and melanotic tumors, showing that this gene is essential for normal development.
- Publication
Science (New York, N.Y.), 1997, Vol 275, Issue 5299, p536
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.275.5299.536