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- Title
Reduced ubiquitin-dependent degradation of c-Jun after phosphorylation by MAP kinases.
- Authors
Musti, A M; Treier, M; Bohmann, D
- Abstract
The proto-oncogene-encoded transcription factor c-Jun activates genes in response to a number of inducers that act through mitogen-activated protein kinase (MAPK) signal transduction pathways. The activation of c-Jun after phosphorylation by MAPK is accompanied by a reduction in c-Jun ubiquitination and consequent stabilization of the protein. These results illustrate the relevance of regulated protein degradation in the signal-dependent control of gene expression.
- Publication
Science (New York, N.Y.), 1997, Vol 275, Issue 5298, p400
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.275.5298.400