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- Title
Activation of interferon-gamma inducing factor mediated by interleukin-1beta converting enzyme.
- Authors
Gu, Y; Kuida, K; Tsutsui, H; Ku, G; Hsiao, K; Fleming, M A; Hayashi, N; Higashino, K; Okamura, H; Nakanishi, K; Kurimoto, M; Tanimoto, T; Flavell, R A; Sato, V; Harding, M W; Livingston, D J; Su, M S
- Abstract
The interleukin-1beta (IL-1beta) converting enzyme (ICE) processes the inactive IL-1beta precursor to the proinflammatory cytokine. ICE was also shown to cleave the precursor of interferon-gamma inducing factor (IGIF) at the authentic processing site with high efficiency, thereby activating IGIF and facilitating its export. Lipopolysaccharide-activated ICE-deficient (ICE-/-) Kupffer cells synthesized the IGIF precursor but failed to process it into the active form. Interferon-gamma and IGIF were diminished in the sera of ICE-/- mice exposed to Propionibacterium acnes and lipopolysaccharide. The lack of multiple proinflammatory cytokines in ICE-/- mice may account for their protection from septic shock.
- Publication
Science (New York, N.Y.), 1997, Vol 275, Issue 5297, p206
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.275.5297.206