We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways.
- Authors
Ichijo, H; Nishida, E; Irie, K; ten Dijke, P; Saitoh, M; Moriguchi, T; Takagi, M; Matsumoto, K; Miyazono, K; Gotoh, Y
- Abstract
Mitogen-activated protein (MAP) kinase cascades are activated in response to various extracellular stimuli, including growth factors and environmental stresses. A MAP kinase kinase kinase (MAPKKK), termed ASK1, was identified that activated two different subgroups of MAP kinase kinases (MAPKK), SEK1 (or MKK4) and MKK3/MAPKK6 (or MKK6), which in turn activated stress-activated protein kinase (SAPK, also known as JNK; c-Jun amino-terminal kinase) and p38 subgroups of MAP kinases, respectively. Overexpression of ASK1 induced apoptotic cell death, and ASK1 was activated in cells treated with tumor necrosis factor-alpha (TNF-alpha). Moreover, TNF-alpha-induced apoptosis was inhibited by a catalytically inactive form of ASK1. ASK1 may be a key element in the mechanism of stress- and cytokine-induced apoptosis.
- Publication
Science (New York, N.Y.), 1997, Vol 275, Issue 5296, p90
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.275.5296.90