We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Semaphorin 3E and plexin-D1 control vascular pattern independently of neuropilins.
- Authors
Gu, Chenghua; Yoshida, Yutaka; Livet, Jean; Reimert, Dorothy V; Mann, Fanny; Merte, Janna; Henderson, Christopher E; Jessell, Thomas M; Kolodkin, Alex L; Ginty, David D
- Abstract
The development of a patterned vasculature is essential for normal organogenesis. We found that signaling by semaphorin 3E (Sema3E) and its receptor plexin-D1 controls endothelial cell positioning and the patterning of the developing vasculature in the mouse. Sema3E is highly expressed in developing somites, where it acts as a repulsive cue for plexin-D1-expressing endothelial cells of adjacent intersomitic vessels. Sema3E-plexin-D1 signaling did not require neuropilins, which were previously presumed to be obligate Sema3 coreceptors. Moreover, genetic ablation of Sema3E or plexin-D1 but not neuropilin-mediated Sema3 signaling disrupted vascular patterning. These findings reveal an unexpected semaphorin signaling pathway and define a mechanism for controlling vascular patterning.
- Publication
Science (New York, N.Y.), 2005, Vol 307, Issue 5707, p265
- ISSN
1095-9203
- Publication type
Journal Article
- DOI
10.1126/science.1105416