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- Title
Autophagy defends cells against invading group A Streptococcus.
- Authors
Nakagawa, Ichiro; Amano, Atsuo; Mizushima, Noboru; Yamamoto, Akitsugu; Yamaguchi, Hitomi; Kamimoto, Takahiro; Nara, Atsuki; Funao, Junko; Nakata, Masanobu; Tsuda, Kayoko; Hamada, Shigeyuki; Yoshimori, Tamotsu
- Abstract
We found that the autophagic machinery could effectively eliminate pathogenic group A Streptococcus (GAS) within nonphagocytic cells. After escaping from endosomes into the cytoplasm, GAS became enveloped by autophagosome-like compartments and were killed upon fusion of these compartments with lysosomes. In autophagy-deficient Atg5-/- cells, GAS survived, multiplied, and were released from the cells. Thus, the autophagic machinery can act as an innate defense system against invading pathogens.
- Publication
Science (New York, N.Y.), 2004, Vol 306, Issue 5698, p1037
- ISSN
1095-9203
- Publication type
Journal Article
- DOI
10.1126/science.1103966