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- Title
Targeting malaria virulence and remodeling proteins to the host erythrocyte.
- Authors
Marti, Matthias; Good, Robert T; Rug, Melanie; Knuepfer, Ellen; Cowman, Alan F
- Abstract
To establish infection in the host, malaria parasites export remodeling and virulence proteins into the erythrocyte. These proteins can traverse a series of membranes, including the parasite membrane, the parasitophorous vacuole membrane, and the erythrocyte membrane. We show that a conserved pentameric sequence plays a central role in protein export into the host cell and predict the exported proteome in Plasmodium falciparum. We identified 400 putative erythrocyte-targeted proteins corresponding to approximately 8% of all predicted genes, with 225 virulence proteins and a further 160 proteins likely to be involved in remodeling of the host erythrocyte. The conservation of this signal across Plasmodium species has implications for the development of new antimalarials.
- Publication
Science (New York, N.Y.), 2004, Vol 306, Issue 5703, p1930
- ISSN
1095-9203
- Publication type
Journal Article
- DOI
10.1126/science.1102452