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- Title
Microbial factor-mediated development in a host-bacterial mutualism.
- Authors
Koropatnick, Tanya A; Engle, Jacquelyn T; Apicella, Michael A; Stabb, Eric V; Goldman, William E; McFall-Ngai, Margaret J
- Abstract
Tracheal cytotoxin (TCT), a fragment of the bacterial surface molecule peptidoglycan (PGN), is the factor responsible for the extensive tissue damage characteristic of whooping cough and gonorrhea infections. Here, we report that Vibrio fischeri also releases TCT, which acts in synergy with lipopolysaccharide (LPS) to trigger tissue development in its mutualistic symbiosis with the squid Euprymna scolopes. As components of PGN and LPS have commonly been linked with pathogenesis in animals, these findings demonstrate that host interpretation of these bacterial signal molecules is context dependent. Therefore, such differences in interpretation can lead to either inflammation and disease or to the establishment of a mutually beneficial animal-microbe association.
- Publication
Science (New York, N.Y.), 2004, Vol 306, Issue 5699, p1186
- ISSN
1095-9203
- Publication type
Journal Article
- DOI
10.1126/science.1102218