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- Title
Early-life blockade of the 5-HT transporter alters emotional behavior in adult mice.
- Authors
Ansorge, Mark S; Zhou, Mingming; Lira, Alena; Hen, René; Gingrich, Jay A
- Abstract
Reduced serotonin transporter (5-HTT) expression is associated with abnormal affective and anxiety-like symptoms in humans and rodents, but the mechanism of this effect is unknown. Transient inhibition of 5-HTT during early development with fluoxetine, a commonly used serotonin selective reuptake inhibitor, produced abnormal emotional behaviors in adult mice. This effect mimicked the behavioral phenotype of mice genetically deficient in 5-HTT expression. These findings indicate a critical role of serotonin in the maturation of brain systems that modulate emotional function in the adult and suggest a developmental mechanism to explain how low-expressing 5-HTT promoter alleles increase vulnerability to psychiatric disorders.
- Publication
Science (New York, N.Y.), 2004, Vol 306, Issue 5697, p879
- ISSN
1095-9203
- Publication type
Journal Article
- DOI
10.1126/science.1101678