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- Title
The complete genome sequence of Propionibacterium acnes, a commensal of human skin.
- Authors
Brüggemann, Holger; Henne, Anke; Hoster, Frank; Liesegang, Heiko; Wiezer, Arnim; Strittmatter, Axel; Hujer, Sandra; Dürre, Peter; Gottschalk, Gerhard
- Abstract
Propionibacterium acnes is a major inhabitant of adult human skin, where it resides within sebaceous follicles, usually as a harmless commensal although it has been implicated in acne vulgaris formation. The entire genome sequence of this Gram-positive bacterium encodes 2333 putative genes and revealed numerous gene products involved in degrading host molecules, including sialidases, neuraminidases, endoglycoceramidases, lipases, and pore-forming factors. Surface-associated and other immunogenic factors have been identified, which might be involved in triggering acne inflammation and other P. acnes-associated diseases.
- Publication
Science (New York, N.Y.), 2004, Vol 305, Issue 5684, p671
- ISSN
1095-9203
- Publication type
Journal Article
- DOI
10.1126/science.1100330